Improving radiotherapy for brain cancers
Dr Ross Carruthers has recently been awarded a CRUK Clinican Scientist Fellowship. A consultant radiation oncologist, now based at the University of Glasgow, he plans to investigate DNA damage response...
View ArticleCommon water treatments could damage DNA
Scientists are warning that a water treatment widely used in developing countries could be damaging the DNA of those drinking it.
View ArticleCancer cells may streamline their genomes in order to proliferate more easily
Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily. The study, conducted in both human and mouse...
View ArticleNight shifts may hinder body's ability to repair DNA damage
Night shift work may hinder the body's ability to repair DNA damage caused by normal cellular processes, suggests a small study published online in Occupational & Environmental Medicine.
View ArticleStudy identifies new gene mutation associated with defective DNA repair and...
Fanconi anemia is a rare genetic disease characterized by hematologic symptoms that include low platelet count and unusually large red blood cells. Mutations in nearly 20 genes have been identified as...
View ArticleStudy sheds light on how body may detect early signs of cancer
Fresh insights into how cells detect damage to their DNA - a hallmark of cancer - could help explain how the body keeps disease in check.
View ArticleErrors made by 'DNA spellchecker' revealed as important cause of cancer
Cancer is mostly caused by changes in the DNA of our cells that occur over a lifetime rather than inherited traits. Identifying the causes of these mutations is a difficult challenge because many...
View ArticleHow DNA damage turns immune cells against cancer
Cancer is essentially a disease of the cell replication cycle. The goal of treating the disease is to permanently kill off the cells that replicate with abandon without any molecular brakes....
View ArticleVitamin therapy may help prevent melanoma
A new review highlights the potential of nicotinamide (Vitamin B3) for preventing melanoma in high-risk individuals.
View ArticleDrug may curb female infertility from cancer treatments
An existing drug may one day protect premenopausal women from life-altering infertility that commonly follows cancer treatments, according to a new study.
View ArticleChronic cell death promotes liver cancer
Liver cancer occurs predominantly in patients whose liver has been damaged as a result of chronic disease. Until now, it was not known how these events are linked at the molecular level. An...
View ArticleAcid reflux cancer link
Esophageal adenocarcinoma (EA) is an increasingly common cancer that silently affects the esophagus – the muscular tube that moves food into stomach. What causes EA is not well known but...
View ArticleDNA damage caused by cancer treatment reversed by ZATT protein
An international team led by scientists at the National Institutes of Health is the first to discover a new way that cells fix an important and dangerous type of DNA damage known as a DNA-protein...
View ArticleScientists discover novel mechanism that protects mitochondrial DNA
Researchers at the University of Eastern Finland have discovered a novel mechanism safeguarding mitochondrial DNA. The study, published in PNAS earlier this week, was carried out in close collaboration...
View ArticleStudy of what makes cells resistant to radiation could improve cancer treatments
A Johns Hopkins University biologist is part of a research team that has demonstrated a way to size up a cell's resistance to radiation, a step that could eventually help improve cancer treatments.
View ArticleResearchers find evidence of DNA damage in veterans with Gulf War illness
Researchers say they have found the "first direct biological evidence" of damage in veterans with Gulf War illness to DNA within cellular structures that produce energy in the body.
View ArticleTiming could matter to how responsive cancer cells are to treatment, study...
DNA damage occurs routinely within your cells due to sun exposure, smoking and sometimes during the normal process of making new DNA. Fortunately, there are "checkpoints" in-place within cells to stop...
View ArticleHow cells detect, mend DNA damage may improve chemotherapy
The busy world inside a cell is directed by its DNA blueprint. When the blueprints are altered, cells can sicken, die or become cancerous. To keep DNA in working order, cells have ways to detect and...
View ArticleScientists take early step to personalized breast cancer care
UT Southwestern Medical Center researchers have developed a method to map protein changes that occur in different subtypes of breast cancer cells in response to DNA damage from a new class of...
View ArticleMechanism identified behind enzyme involved in liver and other human cancers
To understand what has gone wrong when cancer occurs and to create new possibilities for treatment, it is important to understand the molecular mechanisms behind what is happening at the cellular...
View ArticleStressed-out worms hit the snooze button
When you catch a nasty cold, curling up in bed to sleep may be the only activity you can manage. Sleeping in response to stress isn't a uniquely human behavior: many other animals have the same...
View ArticleNovel combination therapy shown to be effective in ovarian cancer
Researchers at The Wistar Institute have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to...
View ArticleLow-dose X-ray exposure does not harm human stem cells
Biophysicists have shown that following low-dose exposure to X-rays (at 80 milligrays), stem cells remain healthy, proliferate, and do not accumulate DNA damage to be passed on to their progeny. The...
View ArticleUncovering molecular targets for childhood cancer therapeutics
Neuroblastoma (NB) is the most common solid tumor found in children. It starts in some very early forms of nerve cells found in the embryo or fetus. Amplification of the gene MYCN is a...
View ArticleNew research shows how alcohol damages DNA and increases cancer risk
Scientists have shown how alcohol damages DNA in stem cells, helping to explain why drinking increases your risk of cancer, according to research part-funded by Cancer Research UK and published in...
View ArticleTargeting breast cancer through precision medicine
University of Alberta researchers have discovered a mechanism that may make cancer cells more susceptible to treatment. The research team found that the protein RYBP prevents DNA repair in cancer...
View ArticleHow incurable mitochondrial diseases strike previously unaffected families
Researchers have shown for the first time how children can inherit a severe - potentially fatal - mitochondrial disease from a healthy mother. The study, led by researchers from the MRC Mitochondrial...
View ArticleWhy mutations that would seemingly affect all cells lead to face-specific...
About 1 in 750 babies born in the United States has some kind of craniofacial malformation, accounting for about one-third of all birth defects.
View ArticleHeadlines saying 'vaping might cause cancer' are wildly misleading
E-cigarettes are in the news again. This time with headlines that they may cause cancer.
View ArticleAlzheimer's disease: Dual mechanism of actions of overactive and cytosolic...
A new study suggests a dual mechanism of actions of overactive and cytosolic re-localized BRCA1, the major guardian of genomic stability, in neurons death by aberrant DNA damage response and presenilin...
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